Another key match in the Round of 16 of the 2025/26 Italian Cup took place, with AC Milan, playing away, losing 0-1 to Lazio after conceding a goal in the second half.

Two minutes into the match, Strashinja fouled Lazio midfielder Matteo Gunduzi while receiving the ball, and the referee showed Strashinja a yellow card. In the third minute, Lazio had a free kick opportunity, and Toma Basic took the shot, but the ball went over the post.

In the 22nd minute, Castellanos received the ball and took a shot from inside the penalty area, but it was cleared by an opposing player. In the 34th minute, Castellanos received a diagonal pass from his teammate at the edge of the penalty area and took a long-range shot, but AC Milan goalkeeper Maignan dived to collect the ball.

In the 45th minute, Lazio's corner kick was blocked by AC Milan goalkeeper Maignan, and Isaksen's volley was then blocked by Maignan.

In the 51st minute of the second half, AC Milan launched an attack. Estupiñán chipped the ball into the penalty area from the left wing, and Cheek immediately rose to head the ball, but it went over the post. In the 60th minute, AC Milan launched a counter-attack from a corner kick, but Lazio goalkeeper Mandas made the save.

In the 71st minute, AC Milan launched a passing combination. Estupiñán, in the penalty area, fell to the ground and passed the ball back to Leão, who volleyed it, but the ball went over the goal. In the 80th minute, Tavares took a corner kick, and Zaccagni rose up and headed the ball into the goal, helping Lazio break the deadlock to 1-0.

In the 81st minute, AC Milan substituted Modric and Pulisic for Yassar and Loftus-Cheek. In the 88th minute, Lazio created an attacking opportunity, and Noslin received the ball in the scramble and shot, but it was saved by AC Milan goalkeeper Maignan.

In the 90th minute, Pulisic received a pass from his teammate in the penalty area and took a shot, but it was blocked by Lazio goalkeeper Mandas.

Ultimately, AC Milan lost 0-1 to Lazio away from home, failing to advance to the quarterfinals of the Italian Cup.